treatment of cns disease with encapsulated inducible choroid plexus cells

摘要

These are compositions and methods that refer to improved treatments for diseases and disorders of the nervous system using semipermeable biocompatible capsules implanted in cns containing encapsulated pathogen-free xenogeneic choroid plexus (cp) cells that are induced to produce levels altered (in certain embodiments, increased) of one or more cerebrospinal fluid (csf) components. The capsules are selected as disclosed to be capable of inducing elevated csf production levels by cp cells that are remarkably long ( 16 months after implantation) without eliciting immune rejection, inflammation or foreign body response reactions. .