Pyrazolo 1,5-a 1,3,5 triazine and pyrazolo 1,5-a pyrimidine derivatives as CDK inhibitors

摘要

The present invention relates to substituted pyrazolo [1,5-a] [1,3,5] triazines of formula (I) useful for treating or preventing disorders or diseases associated with selective transcription CDK in mammals and Derivatives of pyrazolo [1,5-a] pyrimidine and pharmaceutically acceptable salts thereof are provided, which are particularly selective including CDK7, CDK9, CDK12, CDK13 and CDK18, more specifically transcriptional CDK7 inhibitors Useful as a transcriptional CDK inhibitor, where X, Ring A, Ring B, L1, L2, R1, R2, R3, R4, R6, m, n and p have the meanings provided herein. . The present invention relates to a compound of the above formula, a substituted pyrazolo [1,5-a] [1,3,5] triazine and a pyrazolo [1,5-a] pyrimidine derivative of the formula (I) or a pharmaceutically acceptable salt thereof. Also provided is a process for preparing a pharmaceutical formulation comprising at least one possible salt or stereoisomer thereof. [Chemical 1] [Selected figure] None