Process for preparing (S) -CSA salt of S-ketamine, (R) -CSA salt of S-ketamine, and S-ketamine

摘要

The present invention is directed to a process for preparing esketamine. The present invention is further directed to a process for cleaving S-ketamine from racemic, ie, ketamine, an enantiomerically enriched mixture. The present invention further provides a (S) -CSA salt of S-ketamine, more specifically a monohydrate form of (S) -CSA salt of S-ketamine, and a (R) -CSA salt of R-ketamine. Objective.