Methods and compositions for Ebola virus vaccination

摘要

A method for generating an immune response against an Ebola virus antigen using an adenoviral vector that allows multiple vaccinations with the same adenoviral vector and vaccination in individuals with existing immunity against adenovirus Provided. In one aspect, a composition comprising a replication defective adenoviral vector comprising a nucleic acid sequence encoding an Ebola virus antigen is provided, wherein the sequence encoding the Ebola virus antigen is SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 4, It has 70% to 100% sequence identity to a sequence selected from the group consisting of SEQ ID NO: 5, SEQ ID NO: 6, and combinations thereof.