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Improvement of Fe-S cluster request protein activity

机译:Fe-S簇请求蛋白活性的提高

摘要

The present invention is related to a recombinant host cell, in particular a yeast cell, comprising a dihydroxy-acid dehydratase polypeptide. The invention is also related to a recombinant host cell having increased specific activity of the dihydroxy-acid dehydratase polypeptide as a result of increased expression of the polypeptide, modulation of the Fe—S cluster biosynthesis of the cell, or a combination thereof. The present invention also includes methods of using the host cells, as well as, methods for identifying polypeptides that increase the flux in an Fe—S cluster biosynthesis pathway in a host cell.
机译:本发明涉及重组宿主细胞,特别是酵母细胞,其包含二羟基酸脱水酶多肽。本发明还涉及一种重组宿主细胞,其由于该多肽表达的增加,该细胞的Fe&S簇生物合成的调节或其组合而具有增加的二羟基酸脱水酶多肽的比活性。本发明还包括使用宿主细胞的方法,以及鉴定在宿主细胞中增加Fe&S簇生物合成途径中通量的多肽的方法。

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