Micronized eggshell membrane particles and the use of micronized eggshell membrane particles to promote wound healing

摘要

The present invention is a particle consisting essentially of micronized ESM and having an average particle size of less than 100 μm, comprising: (i) an extracellular matrix (ECM) protein and / or a matrix metalloprotease for peptide growth factor or peptide differentiation factor Provided are particles used to promote healing of chronic wounds where (MMP) activity is inappropriate and / or (ii) is or is likely to be an excessive inflammatory response. The present invention further provides a pharmaceutical composition, a wound dressing, and an implantable medical device containing micronized ESM-containing particles used for the treatment. The present invention further provides micronized ESM-containing particles, as well as methods for producing compositions, coatings, and implantable medical devices containing the same.