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Treatment of SIRT1-related diseases by suppression of natural antisense transcripts against sirtuin 1 (SIRT1)

机译:通过抑制针对sirtuin 1(SIRT1)的天然反义转录本来治疗SIRT1相关疾病

摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sirtuin 1 (SIRT1), in particular, by targeting natural antisense polynucleotides of Sirtuin 1 (SIRT1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SIRT1.
机译:本发明涉及特别是通过靶向Sirtuin 1(SIRT1)的天然反义多核苷酸来调节Sirtuin 1(SIRT1)的表达和/或功能的反义寡核苷酸。本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与SIRT1表达有关的疾病和病症中的用途。

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