Anti-TLS monoclonal antibody and production method thereof, hybridoma and production method thereof, and anti-TLS monoclonal antibody-containing composition

摘要

PROBLEM TO BE SOLVED: To provide an anti-TLS monoclonal antibody which can specifically recognize TLS in which an arginine residue is unsymmetrically dimethylated, to provide a method for producing the same, to provide a hybridoma producing the anti-TLS monoclonal antibody, to provide a method for producing the same, and to provide an anti-TLS monoclonal antibody-containing composition which contains the anti-TLS monoclonal antibody.SOLUTION: An anti-TLS monoclonal antibody and the like are obtained by a method comprising a process of administering a peptide consisting of an amino acid sequence represented by CGGRGRGGSG as an immunogen to animals, a process of collecting antibody producing cells from the animals, a process of preparing a hybridoma, and a process of collecting antibodies produced by the selected hybridoma, recognizing TLS in which an arginine residue is unsymmetrically dimethylated.