Target molecule for binding mature amylospheroids to induce mature neuronal cell death, method and substance for inhibiting neuronal cell death induced by amylospheroids, and use thereof

摘要

In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na + /K + -ATPase ±3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na + /K + -ATPase ±3, and the like.