Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-CoA and bacteria expressing same

摘要

An isolated microorganism is disclosed being genetically modified to express pyruvate formate lyase (PFL) or 2-ketobutyrate formate lyase, wherein acetyl-CoA of the microorganism is converted to pyruvate in the presence of formate in a single step reaction, wherein the net flux of the reaction is in the direction of pyruvate synthesis.;Uses of the microorganism and products comprising same are also disclosed.