Inhibitors of diacylglycerol O-acyltransferase 1 (DGAT-1) and uses thereof

摘要

The invention pertains to the use of compounds represented by the formula, Q-G¹-G²-G³-G⁴-Z, where Q is; ;The compounds can be used as diacylglycerol O-acyltransferase 1 (DGAT-1) inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.