首页>
外国专利>
Isobaric tandem mass tags for quantitative proteomics and peptidomics
Isobaric tandem mass tags for quantitative proteomics and peptidomics
展开▼
机译:等量串联质量标签用于定量蛋白质组学和肽组学
展开▼
页面导航
摘要
著录项
相似文献
摘要
Compositions and methods of tagging peptides and other molecules using novel isobaric tandem mass tagging reagents, including novel N, N-dimethylated amino acid 8-plex and 16-plex isobaric tandem mass tagging reagents. The tagging reagents comprise: a) a reporter group having at least one atom that is optionally isotopically labeled; b) a balancing group, also having at least one atom that is optionally isotopically labeled, and c) an amine reactive group. The tagging reagents disclosed herein serve as attractive alternatives for isobaric tag for relative and absolute quantitation (iTRAQ) and tandem mass tags (TMTs) due to their synthetic simplicity, labeling efficiency and improved fragmentation efficiency.
展开▼