A device, system and method are provided for using a seal sub to isolate a well. The seal sub generally has a primary channel extending through the seal sub and seat positioned within the primary channel. As a ball setting tool passes through the seal sub and the seat, a ball connected to the setting tool with a shear pin contacts the seat and selectively connects to the seal sub. A predetermined force can be applied to the ball setting tool to break the shear pin, which leaves the seal ball in place, and the seal sub and the seal ball isolate the downhole pressures and contents from the uphole pressures and contents.
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