Increasing survival of free tissue grafts and flaps using phosphodiesterase type 5 (PDE5) inhibitors

摘要

The present invention relates to methods of tissue grafting and microvascular free flap transfer that involve administering a phosphodiesterase type-5 inhibitor to the tissue graft or microvascular free flap to produce a treated graft or flap, and implanting the treated graft or flap into a recipient site of a host subject.