首页> 外国专利> COMPOSITION FOR THE PREVENTION, IMPROVEMENT, OR TREATMENT OF NEUROLOGICAL DISORDER INCLUDING ADIPONECTIN RECEPTOR-ACTIVATING NOVEL PEPTIDE AS ACTIVE INGREDIENT

COMPOSITION FOR THE PREVENTION, IMPROVEMENT, OR TREATMENT OF NEUROLOGICAL DISORDER INCLUDING ADIPONECTIN RECEPTOR-ACTIVATING NOVEL PEPTIDE AS ACTIVE INGREDIENT

机译:预防,改善或治疗神经系统疾病的组合物,包括作为活性成分的脂联素受体激活型新肽

摘要

A method for preventing, improving or treating a neurological disorder includes administering to a subject a composition including an adiponectin receptor-activating novel peptide as an active ingredient. The adiponectin receptor-activating novel peptide is a peptide consisting of 5 amino acids, and when the adiponectin receptor-activating novel peptide is administered to Alzheimer's model mice, the mice's behavioral changes show that memory and cognitive functions are significantly increased, and APP and amyloid beta (Aβ) proteins are significantly reduced, cytotoxicity does not occur, the proliferation rate of neurons is increased, and cell death is inhibited.
机译:一种预防,改善或治疗神经系统疾病的方法,包括向受试者施用包含脂联素受体激活型新肽作为活性成分的组合物。脂联素受体激活新肽是由5个氨基酸组成的肽,当将脂联素受体激活新肽施用于阿尔茨海默氏症模型小鼠时,小鼠的行为变化表明记忆力和认知功能显着增加,APP和淀粉样蛋白β(Aβ)蛋白显着减少,不会发生细胞毒性,神经元的增殖速率增加,并且细胞死亡受到抑制。

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