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Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
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机译:神经退行性疾病的治疗,记忆增强的原因以及用于筛选此类化合物的测定方法
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摘要
The invention provides methods of enhancing memory and/or learning and prevent neurodegeneration, comprising administering therapeutically effective amounts of certain heterocyclic and aromatic compounds to a patient in need thereof. In one aspect, the invention provides methods of treating patients suffering from a neurodegenerative disease, such as but not limited to, Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease, and/or memory or learning impairment. The invention further provides neuronal human cell-based assays that assess NF-kB gene upregulation using a luciferase reporter, wherein the assays identify compounds that are useful in enhancing memory or learning.
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