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SYSTEM FOR CONTINUOUS MUTAGENESIS IN VIVO TO FACILITATE DIRECTED EVOLUTION
SYSTEM FOR CONTINUOUS MUTAGENESIS IN VIVO TO FACILITATE DIRECTED EVOLUTION
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机译:体内连续诱变促进定向进化的系统
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摘要
A system for continuous mutagenesis to facilitate directed evolution, the system including DNA polymerases carrying the novel K54E point mutation, and other point mutations including I709N, A759R, D424A (herein called K54E_LF Pol I) and this methods of use to produce and detect lines where mutagenesis is continuous and does not exhibit the usual decline in mutagenesis with sequential cloning.
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机译:一种用于连续诱变以促进定向进化的系统,该系统包括带有新型K54E点突变和其他点突变(包括I709N,A759R,D424A(以下称为K54E_LF Pol I))的DNA聚合酶,以及用于生产和检测品系的方法诱变是连续的,并且在顺序克隆中不会表现出通常的诱变下降。
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