ENHANCED DNA SENSING VIA CATALYTIC AGGREGATION OF GOLD NANOPARTICLES BY DNA HYBRIDIZATION CHAIN REACTION

摘要

The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes.