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Process for purifying recombinant plasmodium falciparum circumsporozoite protein

机译：重组恶性疟原虫环子孢子蛋白的纯化方法

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摘要

The present invention relates to processes for purifying high-quality recombinant Plasmodium falciparum circumsporozoite protein at high yields. 展开▼

机译：本发明涉及以高产率纯化高质量的重组恶性疟原虫环子孢子蛋白的方法。展开▼

著录项

公开/公告号US9849177B2

专利类型

公开/公告日2017-12-26

原文格式PDF

申请/专利权人 PFENEX INC.;
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申请/专利号US201514842672

发明设计人 JEFFREY ALLEN;RYAN HAVERSTOCK;
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申请日2015-09-01

分类号A23J1;A61K47/02;C07K14/445;A61K38/17;A61K39;

国家 US

入库时间 2022-08-21 12:57:00

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1. 用于纯化重组恶性疟原虫环子孢子蛋白的方法 [P] . 中国专利： CN104379596B . 2018.05.29

2. 用于纯化重组恶性疟原虫环子孢子蛋白的方法 [P] . 中国专利： CN104379596A . 2015-02-25

3. process for purifying circumsporozoite protein e.g. recombinant falciparum; stable liquid formulation of circumsporozoite protein e.g. recombinant falciparum; and process for stably maintaining rcsp in a stable liquid formulation [P] . BR112014027019A2 . 2017-07-11

机译：纯化环子孢子蛋白的方法，例如重组恶性疟稳定的环子孢子蛋白液体制剂，例如重组恶性疟和将rcsp稳定保持在稳定液体制剂中的方法

4. PROCESS FOR PURIFYING RECOMBINANT PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN [P] . 欧洲知识产权局专利： EP2844666B1 . 2019-07-17

机译：纯化重组恶性疟原虫环孢子蛋白的方法

5. PROCESS FOR PURIFYING RECOMBINANT PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN [P] . CA2870198C . 2019-12-03

机译：纯化重组恶性疟原虫环孢子蛋白的方法

1. Role of toll-like receptor 4 in eliciting adaptive immune responses against recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum [J] . Muhammad A.Abbas, Rapeah Suppian 亚太热带生物医学杂志（英文版） . 2019,第001期

2. Role of toll-like receptor 4 in eliciting adaptive immune responses against recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum [J] . Muhammad A.Abbas, Rapeah Suppian 亚太热带生物医学杂志：英文版 . 2019,第001期

3. Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1 [J] . Mohamed H Abdikarim, Muhammad A Abbas, Munirah N Zakaria, 亚太热带生物医学杂志（英文版） . 2019,第007期

4. Pam3CSK4 enhances adaptive immune responses to recombinant Mycobacterium bovis bacille Calmette-Guérin expressing Plasmodium falciparum C-terminus merozoite surface protein-1 [J] . Mohamed H Abdikarim, Muhammad A Abbas, Munirah N Zakaria, 亚太热带生物医学杂志：英文版 . 2019,第007期

5. A recombinant Bacille Calmette-Guerin construct expressing the Plasmodium falciparum circumsporozoite protein enhances dendritic cell activation and primes for circumsporozoite-specific memory cells in BALB/c mice. [J] . Arama C, Waseem S, Fernandez C, Vaccine . 2012,第37期

6. Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guerin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice. [J] . Arama C., Assefaw-Redda Y., Rodriguez A., Vaccine . 2012,第27期

7. The humoral immune responses elicited in mice by inoculations with a recombinant protein or DNA based on the circumsporozoite-protein gene of Plasmodium falciparum. [J] . Fang Z, Liu YW, Shi YK, Annals of tropical medicine and parasitology . 2002,第5期

8. Identification and quantitation of Plasmodium falciparum and Anopheles gambiae proteins from Plasmodium parasite infected mosquitoes [C] . Raghothama Chaerkady, Mobolaji Okulate, Kumaran Kandasamy, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

9. Variation in the Circumsporozoite Protein of Plasmodium falciparum: Implications for Vaccine Development. [D] . Gandhi, Kavita. 2013

10. Induction of cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein by immunization with soluble recombinant protein without adjuvant. [O] . A Malik, M Gross, T Ulrich, 1993

11. Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guérin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice [O] . Arama Charles, Assefaw-Redda Yohannes, Rodriguez Ariane, 2012

1. The humoral immune responses elicited in mice by inoculations with a recombinant protein or DNA based on the circumsporozoite-protein gene of Plasmodium falciparum [J] . FANGZheng LIUYanwen SHIYukun . 南通医学院学报 . 2003,第2期

2. 应用无细胞系统表达恶性疟原虫环子孢子蛋白 [C] . 韩静 ,杨英超 ,辛晓芳 . 2010年中国药学大会暨第十届中国药师周大会 . 2010

3. 麦胚无细胞蛋白合成系统表达恶性疟原虫环子孢子蛋白的研究 [A] . 韩静 . 2011