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OXIDIZING AGENT FOR 5-HYDROXYMETHYLCYTOSINE AND METHOD FOR ANALYZING 5-HYDROXYMETHYLCYTOSINE
OXIDIZING AGENT FOR 5-HYDROXYMETHYLCYTOSINE AND METHOD FOR ANALYZING 5-HYDROXYMETHYLCYTOSINE
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机译:5-羟甲基胞嘧啶的氧化试剂和5-羟甲基胞嘧啶的分析方法
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摘要
The purpose of the present invention is to develop and provide a less expensive and novel oxidizing agent for 5-hydroxymethylcytosine, which can selectively oxidize 5-hydroxymethylcytosine on DNA into 5-formylcytosine while preventing the DNA structure from destabilization and suppressing side reactions, and a method for detecting a demethylation site at a high accuracy in demethylation of DNA with the use of the aforesaid oxidizing agent.;Provided is an oxidizing agent for 5-hydroxymethylcytosine that comprises a nitroxyl radical molecule and a copper salt or a copper complex, and/or a nitroxyl radical molecule-copper complex.
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