Process and intermediates for the synthesis of 8-{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl-8-phenyl-1,7-diaza-spiro4.5decan-2-one compounds

摘要

This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.