首页> 外国专利> Biespecu00cdficos Antibody to the Protein of Programmed Cell Death 1 (PD1) and for the Human Protein that belongs to the Superfamily of immunoglobulin (tim3)

Biespecu00cdficos Antibody to the Protein of Programmed Cell Death 1 (PD1) and for the Human Protein that belongs to the Superfamily of immunoglobulin (tim3)

机译:Biespec u003cdficos程序性细胞死亡1(PD1)蛋白和属于免疫球蛋白超家族(tim3)的人类蛋白的抗体

摘要

The Disclosure relates to Antibodies which comprise a First biespecu00edficos Antigen binding site that specifically binds to a Second PD1 and Antigen binding site that specifically binds to tim3, in particular biespecu00edficos Antibodies in the Antibody biespecu00edfi Co binds to tim3 with a Lower Affinity compared with the Union PD1.The Disclosure further relates to methods for producing these molecules and Methods for using the same in the Prevention or treatment of cancer.
机译:本公开涉及包含特异性结合至第二PD1的第一biespec抗原的结合位点和特异性结合tim3的抗原结合位点的抗体,特别是抗体biespec抗体中的抗体与抗体3结合tim3。与Union PD1相比,亲和力较低。本公开进一步涉及产生这些分子的方法以及将其用于预防或治疗癌症的方法。

著录项

  • 公开/公告号AR106198A1

    专利类型

  • 公开/公告日2017-12-20

    原文格式PDF

  • 申请/专利权人 F. HOFFMANN-LA ROCHE AG;

    申请/专利号AR2016P102983

  • 发明设计人

    申请日2016-09-29

  • 分类号C07K16/28;C12N1/21;C12N5/10;C12N15/13;C12N15/63;

  • 国家 AR

  • 入库时间 2022-08-21 12:54:16

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