TrkB agonists Union, Nucleic Acid sequences which ENCODE, Expression Vectors comprising the recombinant host Cell, comprising such sequences.Method for the production of the agonist, Pharmaceutical composition containing the composition and its use for the manufacture of

摘要

A Union of TrkB agonist, wherein Said Power agonism of TrkB agonist induced by BDNF and / or induced by NT - 4.The levels of TrkB agonist remains at the cell surface and can bind to an epitope within the film B and G, and the region between the sheets a and B ', the D5 domain of TrkB.One or more Nucleic Acid sequences which Encode the Union of TrkB agonist; one or more Expression Vectors comprising the Nucleic Acid sequences of one or more; a host Cell recombiThat includes one or more Nucleic Acid sequences or the one or more expression vector; and a method for the production of the Union of TrkB agonist which comprises cultivating the cell HueSpEd in conditions suitable for the expression of the Nucleic Acid Sequence or vector.A Pharmaceutical composition comprising the Union of TrkB agonist, and one or a combination of vehicles or pharmaceutically acceptable excipients, diluents.Use of Union of TrkB agonist for the manufacture of a Pharmaceutical composition for the treatment of a Neurological disorder or other disorder or the restoration or augmentation of the routeBDNF TrkB Activation of TrkB may be beneficial.Preferably, the Disorder is a neurodegenerative disease, Optic neuropathy, a degenerative disorder of the retina, a Disorder that involves hearing lossA Psychiatric Disorder, a Neurodevelopmental Disorder, a disorder of body weight Regulation, a Muscle disorder and other disorders of the CNS.More preferably, the Disorder is: Amyotrophic Lateral Sclerosis (ALS) and Huntington's Disease (HD), Alzheimer's Disease (AD), motor Neuron disease, Parkinson's disease,Prion disease, Lewy body disease, Spinal Muscular Atrophy, multiple Systems atrophy, Dementia and tauopathies, glaucoma, anterior ischemic Optic neuropathy (Aion)Posterior ischemic Optic neuropathy, neuropathy Optic Radiation Optic neuropathy, compressive Optic neuropathy mitochondrial Toxic Optic neuropathy, traumatic Optic Neuropathy.A Hereditary Optic neuropathy, Optic neuritis, age-related Macular Degeneration, retinitis pigmentosa, neural Deafness, Cochlear Deafness, sensorineural hearing loss, tinnitusHearing Loss composed, mood disorder, anxiety, depression, Panic Disorder, Post Traumatic Stress Disorder (PTSD), Attention deficit hyperactivity disorder (ADHD).Bipolar Disorder, Schizophrenia, Angelman Syndrome, Prader Willi Syndrome, autistic Disorder, Rett syndrome, anorexia, cachexia, unintended Weight Loss, obesity, Sarcopenia,Emesis induced by opioids, Sarcopenia, diabetic neuropathy, multiple sclerosis, Epilepsy, Migraine, nerve damage, Peripheral Neuropathy, Neuromuscular Disease, Sleep Disorder and Stroke.