首页> 外国专利> Monoclonal antibody after Incubation with the peptides monomu00c9ricos ab 1 - 42 Inhibits the aggregation of the monomers to AB fibrils or High Molecular Weight polymeric filaments

Monoclonal antibody after Incubation with the peptides monomu00c9ricos ab 1 - 42 Inhibits the aggregation of the monomers to AB fibrils or High Molecular Weight polymeric filaments

机译:与肽monom u00c9ricos ab 1-42孵育后的单克隆抗体抑制单体聚集到AB原纤维或高分子量聚合物丝上

摘要

A monoclonal antibody that includes any functionally equivalent or Functional parts of the sameAntibody after co Incubation with monomeric peptides ab 1 - 42 Inhibits the aggregation of fibrils or AB monomers to Polymer filaments of high molecular weight.And after co Incubation with Amyloid fibrils or High Molecular Weight polymeric filaments Preformed, formed by the aggregation of monomeric Peptides, ab 1 - 42Is able to disaggregate Preformed polymeric Fibres or filaments, a polinucleu00f3tido comprising a Nucleotide sequence that encodes this monoclonal antibody.A composition comprising such a compound and the use of Monoclonal Antibodies, the monoclonal antibody for the preparation of a Medicine, a method for producing Said Antibody,A method for the preparation of a Pharmaceutical composition, a hybridoma cell line and a method of Diagnosis and monitoring of disease.
机译:与单体肽ab 1-42共孵育后,包含同一抗体的任何功能等同或功能部分的单克隆抗体,可抑制原纤维或AB单体聚集到高分子量的聚合物长丝上;与淀粉样蛋白原纤维或高分子共孵育后重量很重的聚合物长丝,是由单体肽的聚集体形成的,ab 1-42Is能够分解预制的聚合物纤维或长丝,包括一个编码该单克隆抗体的核苷酸序列的多聚核糖核酸,包含这种化合物的组合物以及其用途单克隆抗体,用于制备药物的单克隆抗体,用于制备所述抗体的方法,用于制备药物组合物的方法,杂交瘤细胞系以及疾病的诊断和监测方法。

著录项

  • 公开/公告号AR107352A2

    专利类型

  • 公开/公告日2018-04-18

    原文格式PDF

  • 申请/专利权人 AC IMMUNE S.A.;

    申请/专利号AR2017P100086

  • 发明设计人

    申请日2017-01-12

  • 分类号C07K16/18;A61K39/395;A61P25/28;C12N15/13;G01N33/577;

  • 国家 AR

  • 入库时间 2022-08-21 12:54:18

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