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methods and systems for pharmacogenomic treatment of cardiovascular conditions

机译:心血管疾病药物基因组学治疗的方法和系统

摘要

methods and systems for pharmacogenomic treatment of cardiovascular conditions. The present invention relates to systems and methods that are based on the effects of genetic variations of biological activities associated with rostafuroxin in an individual. In particular, systems, methods and compositions are described herein which are based on an identified influence on an individual rostafuroxin response of one or more polymorphisms in an intergenic or intragenic region of a gene selected from the group consisting of kcns3, thsd7a, fam46a, loc389970, hla-g, and ttc29, and / or a genetic variation in binding imbalance with it.
机译:药物基因组学治疗心血管疾病的方法和系统。本发明涉及基于个体中与罗他福辛相关的生物活性的遗传变异的影响的系统和方法。特别地,本文描述的系统,方法和组合物是基于对基因的基因间或基因内区域中的一种或多种多态性的个体罗斯塔福星反应的确定影响,所述基因选自kcns3,thsd7a,fam46a,loc389970 ,hla-g和ttc29,和/或结合不平衡的遗传变异。

著录项

  • 公开/公告号BR112012009144A2

    专利类型

  • 公开/公告日2018-10-16

    原文格式PDF

  • 申请/专利权人 ROSTAQUO S.P.A;

    申请/专利号BR20121109144

  • 申请日2010-10-18

  • 分类号A61K31/56;A61P9;

  • 国家 BR

  • 入库时间 2022-08-21 12:54:11

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