fusion protein, isolated outer membrane vesicle, polynucleotide, pharmaceutical composition, vaccine, method for treating or preventing neisseria infection or disease, use and method for making a fusion protein

摘要

fusion protein, isolated outer membrane vesicle, polynucleotide, pharmaceutical composition, vaccine, method for treating or preventing neisseria infection or disease, use and method for making a fusion protein The present invention relates to the field of immunogenic compositions and vaccines against neisseria, its manufacture, and the use of such compositions in medicine. chimeric fhbp proteins (h-factor binding protein), and compositions comprising said proteins, are described to overcome the fhbp immune response problem which is specific to the meningococcal strain from which fhbp was derived.