compounds, methods for inhibiting mir-21 activity, method for decreasing collagen expression, method for treating, preventing or delaying the onset of a disease, method for treating a fibroproliferative disorder and uses of a compound.

摘要

Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.