methods for treating or delaying, reducing or inhibiting cancer relapse or progression and the progression of an immune-related disease in an individual, to increase, improve or stimulate an immune response or function in an individual and kit.

摘要

The present invention describes the combined treatment comprising a pd-1 axis binding antagonist and an agent that decreases or inhibits tigit expression and / or activity and methods for its use, including methods of treating conditions in which it is present. Enhanced immunogenicity such as enhancing tumor immunogenicity for the treatment of cancer or chronic infection is desired.