antibody capable of neutralizing the substance having alternative activity for coagulation factor function viii (fviii)

摘要

The present invention relates to an antibody capable of neutralizing the activity of a substance having an alternative activity for fviii function for the purpose of using the antibody in a method for measuring fviii reactivity in the presence of the substance having alternative activity. for the fviii function. As a result, the inventors found that when the produced antibody is used, fviii activity in a haemophilia patient's plasma can be accurately assessed in an aptt-based one-stage coagulation assay and also found that the titer of a plasma fviii inhibitor from a haemophilia patient carrying the fviii inhibitor can be accurately evaluated in the aptt-based bethesda assay.