recombinant alpha galactosidase a and / or biologically active recombinant alpha galactosidase fragment, composition, recombinant polynucleotide sequence, expression vector, host cell, methods for producing a variant alpha galactosidase ae for treating and / or preventing symptoms of fabry, pharmaceutical composition, and, use of compositions.

摘要

The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. Engineered human alpha-galactosidase polypeptides have been enhanced to provide improved stability under both acidic (ph 4.5) and basic (ph 7) conditions. The invention also relates to the use of compositions comprising engineered human alpha-galactosidase polypeptides for therapeutic purposes.