serine protease cleavable and matrix metalloprotease cleavable substrates and methods of use thereof

摘要

The invention generally relates to polypeptides comprising at least a first cleavable portion (cm1) which is a substrate for at least one matrix metalloprotease (mmp) and at least a second cleavable portion (cm2) which is a substrate for at least one. a serine protease (sp), activatable antibodies and other larger molecules including these polypeptides which include at least one cm1 which is a substrate for at least one mmp protease and at least one cm2 that is a substrate for at least one protease sp, and methods of making and using these polypeptides which include at least one cm1 which is a substrate for at least one mmp protease and at least one cm2 which is a substrate for at least one sp protease in a variety of therapeutic, diagnostic and prophylactic indications. .