human anti-vegfr2 antibody for antiangiogenic and targeted cancer therapy

摘要

The present invention relates to an isolated antibody or antigen binding fragment thereof having a specific binding affinity for an epitope located within the domain 1 or domain 3 of the human vascular endothelial growth factor receptor 2 (vegfr2; seq. id: 74). the epitope within domain 3 of vegfr2 is located between amino acid residues 250 and 270 of sequence: 74. the use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament to inhibit tumor development, The angiogenesis of the tumor, and / or to induce cytotoxicity of cancer cells in an individual in need thereof is also described. A method of detecting the presence of vegfr2 in a vascular tumor endothelial cell or a cancer cell in a biological sample is also described.