首页> 外国专利> Three formulations with a percutaneous with only the active principle exemestane for control of flavouring.Another formulation with the active principles with exemestane and testosterone for male hormone replacement with control of flavouring and the other with only the active principle testosterone to reposiçãThe hormonal without control of flavouring.

Three formulations with a percutaneous with only the active principle exemestane for control of flavouring.Another formulation with the active principles with exemestane and testosterone for male hormone replacement with control of flavouring and the other with only the active principle testosterone to reposiçãThe hormonal without control of flavouring.

机译:三种配方中仅含活性成分依西美坦的经皮制剂用于控制调味剂。另一种配方中具有依西美坦和睾丸激素的有效成分用于替代男性荷尔蒙并控制调味剂,另一种制剂仅含有效成分睾丸激素用于调配荷尔蒙而不控制调味剂。

摘要

The invention here presented is intended: the industrial area, to the pharmaceutical industry.As to the area of medicine is a hormone replacement and the control of flavouring agent in patients who have this need.Refers to three pharmaceutical formulations for transdermal drug administration net.It is characterized by comprising: (I) a quantity of clinically effective exemestane; (II) a clinically effective amount of testosterone; (III) propylene glycol as the sole solubilizing andOnly one excipient QSP.In preferred compositions of the invention concentrations, the function such as anti odorant of gradual release for the control of flavouring in patients with breast cancer, skin.Benign and malignant prostate hyperplasia and other problems caused by the disturbance of flavouring.When formulated with exemestane and testosterone exerts the function of male hormone replacement for release / gradual uptake of testosterone.Respecting the circadian cycle and controlling the flavouring of, through the gradual release and concomitant of exemestane, maintaining the balance between testosterone and estrogen.When formulated with only testosterone realization the function of hormone replacement without control of flavouring.
机译:这里提出的本发明旨在:工业领域,用于制药工业。关于药物领域,是有此需要的患者中的激素替代和调味剂的控制。参见用于经皮药物施用网的三种药物制剂。其特征在于包括:(I)一定量的临床有效的依西美坦; (II)临床有效量的睾丸激素; (III)丙二醇作为唯一的增溶剂,并且仅是一种赋形剂QSP。在本发明的优选组合物中,其浓度例如逐渐释放的抗臭剂用于控制乳腺癌,皮肤病患者,良性和恶性前列腺增生和依西美坦与睾丸激素配合使用时,可发挥雄性激素替代功能,以逐渐释放/逐渐吸收睾丸激素;通过依西美坦的逐步释放与伴随,重新观察昼夜周期并控制其风味,维持睾丸激素和雌激素之间的平衡。仅使用睾丸激素配制时,即可实现激素替代功能,而无需控制调味剂。

著录项

  • 公开/公告号BR102018008283A2

    专利类型

  • 公开/公告日2018-11-06

    原文格式PDF

  • 申请/专利权人 MARIO VIRGILIO DE CARVALHO JUNIOR;

    申请/专利号BR20181008283

  • 发明设计人 MARIO VIRGILIO CARVALHO JUNIOR;

    申请日2018-04-24

  • 分类号A61K31/568;A61K31/5685;A61P5/24;A61P35/00;

  • 国家 BR

  • 入库时间 2022-08-21 12:53:34

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