首页> 外国专利> Two formulations of exemestane percutaneous, one for control of flavouring in cancer of the breast, skin,Pru00f3statas and other disturbances of flavouring and another of testosterone with or without exemestane for hormone replacement with or without control of flavouring

Two formulations of exemestane percutaneous, one for control of flavouring in cancer of the breast, skin,Pru00f3statas and other disturbances of flavouring and another of testosterone with or without exemestane for hormone replacement with or without control of flavouring

机译:两种依西美坦经皮制剂,一种用于控制乳腺癌,皮肤癌,Pr nstatas和其他风味紊乱的调味剂,另一种在有或没有西美司坦的情况下用于睾丸激素的激素替代,无论有无香料控制

摘要

Two formulations of exemestane percutaneous, one for control of flavouring in cancer of the breast, skin,Pru00f3statas and other disturbances of flavouring and another of testosterone with or without exemestane for hormone replacement with or without control of flavouring.The invention is now presenting refers to two pharmaceutical formulations for transdermal drug administration net.It is characterized by comprising: (I) a quantity of clinically effective exemestane; (II) a clinically effective amount of testosterone; (III) propylene glycol as the sole solubilizing andOnly one excipient QSP.In preferred compositions of the invention concentrations, the function such as anti odorant of gradual release for the control of flavouring in patients with breast cancer, skin.Benign and malignant prostate hyperplasia and other problems caused by the disturbance of flavouring.When formulated with exemestane and testosterone exerts the function of male hormone replacement for release / gradual uptake of testosterone.Respecting the circadian cycle and controlling the flavouring of, through the gradual release and concomitant of exemestane, maintaining the balance between testosterone and estrogen.When formulated with only testosterone realization the function of hormone replacement without control of flavouring.
机译:两种经皮的依西美坦制剂,一种用于控制乳腺癌,皮肤癌,Pr nstatas和其他风味的紊乱,另一种具有或不具有依西美坦的睾丸激素替代或不具有香料的激素替代激素。现在提出本发明指用于透皮给药网络的两种药物制剂。其特征在于包括:(I)一定量的临床有效的依西美坦; (II)临床有效量的睾丸激素; (III)丙二醇作为唯一的增溶剂,并且仅是一种赋形剂QSP。在本发明的优选组合物中,其浓度例如逐渐释放的抗臭剂用于控制乳腺癌,皮肤病患者,良性和恶性前列腺增生和依西美坦与睾丸激素配合使用时,可发挥雄性激素替代功能,以逐渐释放/逐渐吸收睾丸激素;通过依西美坦的逐步释放与伴随,重新观察昼夜周期并控制其风味,维持睾丸激素和雌激素之间的平衡。仅使用睾丸激素配制时,即可实现激素替代功能,而无需控制调味剂。

著录项

  • 公开/公告号BR102017020161A2

    专利类型

  • 公开/公告日2018-06-19

    原文格式PDF

  • 申请/专利权人 MARIO VIRGILIO DE CARVALHO JUNIOR;

    申请/专利号BR20171020161

  • 发明设计人 MARIO VIRGILIO CARVALHO JUNIOR;

    申请日2017-09-20

  • 分类号A61F13/02;A61K9/70;A61K31/568;A61K31/5685;A61P5/26;A61P35/00;

  • 国家 BR

  • 入库时间 2022-08-21 12:53:55

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