antibodies that bind to sortilin and inhibit progranulin binding, pharmaceutical compositions, preparations thereof, use of antibodies, kit and method for preventing or treating a disease associated with decreased levels of pgrn

摘要

The present invention relates to anti-sortiline monoclonal antibodies which have been found to be useful in correcting a deficient progranulin level (pgrn). in particular, these antibodies may be used in the treatment of frontotemporal dementia (ftd) and amyotrophic lateral sclerosis (als).