inclusion complexes of benzaldehyde semicabazone in cyclodextrins and their method of preparation

摘要

"process for preparing semicarbazone and / or thiosemicarbazone formulations with cyclodextrins and their derivatives and products obtained therefrom". The present invention is characterized by the preparation of formulations of semicarbazones and / or thiosemicarbazones with cyclodextrins and their derivatives and products obtained therefrom. The present invention is characterized by the inclusion of semicarbazones and / or thiosemicarbazones inclusion compounds in cyclodextrins and their derivatives which, tested in experimental models of epilepsy, allowed the reduction of anticonvulsant dose from 100mg / kg to 35mg / kg. means increased bioavailability of compounds in biological systems. These results obtained in animal models place the semicarbazones and / or thiosemicarbazones included in cyclodextrins and their derivatives as candidates for new anticonvulsant agents. The present invention is further characterized by the increased efficacy of semicarbazones and / or thiosemicarbazones included in cyclodextrins and their derivatives as compared to free components.