Nucleoside Agents for reducing the harmful activity of genes containing Extended nucleotide repeats.

摘要

p THE ASPECTS OF THE INVENTION INCLUDE MEacute; ALL FOR THE REDUCTION OF THE HARMFUL ACTIVITY OF AN OBJECTIVE GENE CONTAINING A REPETITION OF NUCLEOacute; TIDOS (NR, BY THEIR CENTURIES IN ENGLISH) IN A CEacute; LULA THROUGH THE CONTACT OF THE CEacute; LULA WITH AN EFFECTIVE AMOUNT OF A NUCLEOAcute AGENT, ASIacute; AS ALSO COMPOSITIONS USED IN SUCH MEacute; ALL. HARMFUL ACTIVITY (FOR EXAMPLE,TOXICITY AND / OR DYSFUNCTIONALITY OF PRODUCTS CODED BY THIS) OF AN OBJECTIVE GENE CONTAINING MUTANT EXTENDED NR MAY BE REDUCED IN A VARIETY OF DIFFERENT FORMS, FOR EXAMPLE, THROUGH REDUCTION; AND (IN SOME CASES, REDUCE THEMSELVES; INCLUDES SELECTIVE) THE PRODUCTION, NON-ACTIVITY OF THE EXPRESSION PRODUCTS, TOXIC (FOR EXAMPLE, RNA OR PROTEINATION) CODED BY THE OBJECTIVE GENE. KITS AND COMPOSITIONS ARE ALSO PROVIDED TO PUT ON THE MEacute; ALL OBJECT. /p