N - acilsulfonamida compounds that inhibit the activity of antiapoptotic Proteins bcl2 and its use in the manufacture of a Medicament for the treatment of Cancer and Immune diseases and AutoImmune

摘要

N-acylsulfonamide compounds are disclosed, for example, N - ({3-chloro-4 - [(4- fluorotetrahydro-2H-pyran-4-yl) methoxy] phenyl} sulfonyl) -4- (4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl) -2 - [(6-fluoro-1H-indole-5-yl) oxy] benzamide, which inhibit the activity of Bcl-2 antiapoptotic proteins, compositions containing said compounds and their use in the manufacture of a medicament for the treatment of cancer and immune and autoimmune diseases. The compounds and compositions described in the present application are useful against bladder cancer, brain cancer, breast cancer, bone marrow cancer, cervical cancer,Chronic lymphocytic leukemia, rectal cancer, esophageal cancer, liver cancer, lymphocytic leukemia, lymphocytic lymphoma, folk lymphoma, which is a kind of malignant lymphoma, melanoma, myeloma, myeloma, oral cancer, ovarian cancer, non-small cell lung cancer caused by T cell or B cell, Prostate cancer, small cell lung cancer or spleen cancer.