Dihidroisoquinolinas derived compounds or their salts as inhibitors of the activity of antiapoptotic Proteins BCL XL; Pharmaceutical composition that is useful for the treatment of bladder cancer, Breast, Brain, Bone Marrow, esophageal, colorectal, ovarian, Leuc Chronic Lymphocytic EMIA, or cancer of the Spleen, among others.

摘要

Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and compounds (I) for use in the methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.