SYNTHESIS OF 5', 5' -DIBUTYL-3', 3' -DIMETHYLPIRO BENZOC1,2 OXATHIOLE-3,2'-4,6- DIOXA-5-STANNA-1,3(1,4)-DIBENZENACYCLOHEXAPHANE1,1-DIOXIDE FOR THERAPEUTIC APPLICATIONS

摘要

The present invention provides synthesis of 5t,5!-dibutyl-3t 3tdimethylspiro[ benzo[c][l32]oxathiole-352-456-dioxa-5-stanna-l ,3(1,4)- dibenzenacyclohexaphane] 1,1 -dioxide. The complex is synthesized by conventional method. 0.22 g of dibutyltin(IV) pxide was used as starting material to which mixture of ligand (3,3-bis(4-hydroxy-3-methylphenyl)-3Hbenzo[ c][l,2]oxathiole 1,1 -dioxide), dry benzene (60 ml) and absolute ethanol (20 ml) are added. The reaction mixture is refluxed azeotropically for 5.5 hrs. After removal of water from the reaction mixture, the product obtained is extracted and washed with chloroform and dried in vacuum. The product obtained is characterized by UV -Visible and H NMR, 13CNMR.