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FORMULATION FOR FAST DISINTEGRATING THIN FILM OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE AND PREPARATION OF 2-HP--CD COMPLEX THEREOF
FORMULATION FOR FAST DISINTEGRATING THIN FILM OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE AND PREPARATION OF 2-HP--CD COMPLEX THEREOF
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机译:快速拆分三乙咪唑三水合镁薄膜的制备及其2-HP-CD络合物的制备
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摘要
An orally fast disintegrating formulation of a drug for oral administration is provided. The formulation includes Esomeprazole Magnesium Trihydrate (EMT) as a film. The formulation includes 2-HP--Cyclodextrin complex of the drug. The formulation also includes a plasticizer, a film forming agent, a preservative and a flavorings agent. The fast disintegrating thin film of Esomeprazole magnesium trihydrate (EMT) is prepared by solvent casting method. A number of different types of film forming agents and plasticizers are used and through them a polymer and a plasticizer is chosen for an optimal formulation.
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