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A PROCESS FOR SYNTHESIS OF FLAVONOL AND ITS ANTI-INFLAMMATORY ACTIVITY
A PROCESS FOR SYNTHESIS OF FLAVONOL AND ITS ANTI-INFLAMMATORY ACTIVITY
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机译:黄酮醇的合成及其抗炎活性
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0051 A process for synthesis of flavonol and its anti-inflammatory activity 0052 The invention relates to a process for chemical synthesis of a flavonol from an aromatic ketone and an aromatic aldehyde using a two-step process of ClaisenSchmidt condensation process followed by Algar-Flynn-Oyamada process. The invention also discloses the anti-inflammatory activity of the synthesized flavonol. The first step of chemical synthesis is ClaisenSchmidt condensation process, in which the ketone is reacted with aldehyde to obtain a chalcone. The second step is Algar-Flynn-Oyamada synthesis, in which chalcone synthesized in the first step is processed with alcoholic sodium hydroxide to obtain the final product flavonol. Flavonol synthesized in the present invention is identified as 2- (4-benzyloxyphenyl)-3-hydroxy-chromen-4-one and exhibited improved physical properties. Further, flavonol at the concentration of 200 mg/kg exhibited anti-inflammatory activity by reducing paw volume and preventing the elevation of WBC count in rats with paw edema. (Figure 1)
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