SYNTHESIS OF N2- FURFURYL DEOXYGUANOSINE PHOSPHORAMIDITE AND MODIFIED OLIGONUCLEOTIDES

摘要

N2-furfuryl deoxyguanosine phosphoramidite compound of formula 4 is provided which are building blocks for synthesis of modified DNA. A process of synthesis of N2 -furfuryl deoxyguanosine phosphoramidite is also provided which is safe and economically viable. The modified amidite has been successfully incorporated into oligonucleotides by solid phase DNA synthesis. [IN-MUM-2013-00454A]