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NOVEL METHODS AND KITS FOR DETECTING UREA CYCLE DISORDERS USING MASS SPECTROMETRY.
NOVEL METHODS AND KITS FOR DETECTING UREA CYCLE DISORDERS USING MASS SPECTROMETRY.
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机译:质谱法检测尿素循环异常的新方法和试剂盒。
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摘要
The present invention relates to newborn screening kits, methods, stable isotopically-labeled internal standards or internal standard solution for high throughput screening and analysis of metabolic disorders using liquid chromatography mass spectrometry (LC-MS) are provided. The metabolic disorders can be amino acid, organic acid or fatty acid oxidation disorders, and particularly urea cycle disorders or deficiencies, hyperammonemia, Hyperornithinemia- hyperammonemia-homocitrullinuria (HHH), and/or argininosuccinic aciduria. The newborn screening kits, methods, stable isotopically-labeled internal standards or internal standard solution are particularly useful for newborn screening (NBS) of metabolic disorders.
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