HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4.

摘要

An isolated human antibody or a fragment of a human antibody which specifically binds to human delta-like ligand 4 (hDII4) and blocks hDII4 binding to a Notch receptor. The human anti- hDII4 antibody or antibody fragment binds hDII4 with an affinity of =¤ 500 pM, as measured by surface plasmon resonance.