Pyridine compounds and their applications as MFN receiver modulators

摘要

It refers to a formula compound: where x is ar-o-ar, among others; R1 is hydrogen, halogen, etc.; R2 is alcox C1-C6, R3 is hydrogen, C1-C6 tar, etc.; R4 is hydrogen, C1-C6 tar; R5 is hydrogen or C1-C6 tar; R6 is hydrogen or C1-C6 tar. 1. The preferred compound is 2 - [(n-acetylene) methyl] - 7-methylpyridan [1,2-a] pyridine-4-ona;2 - [(n-ethyl-4-fluoro-anilino) methyl] pyridine [1, 2-A] pyridine-4-ona, etc. For the treatment of NCRE related diseases and conditions, the preparation and use of NR2A positive Western Sahara modulator were provided.