The fourth member of tumor necrosis factor (OX40) receptor and its antibody

摘要

It refers to an isolated antibody, which is fixed on human OX40, including SEQ ID n ° 87, SEQ ID n ° 87, CDR2, SEQ ID n ° 88 and CDR3, SEQ ID n ° 89, as well as SEQ ID n ° 90, CDR2, SEQ ID n ° 91 and CDR3, SEQ ID n ° 92, light chain. The sequence of heavy chain variable region was SEQ ID n ° 318, and that of light chain variable region was SEQ ID n ° 94. It also mentions a nucleic acid that encodes heavy and light chain variable regions, an expression vector and a pharmacological synthesis. This antibody is an effective treatment for cancer