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Variation of reduction factor VIII, together with CpG, components and methods of hemophilia and treatment

机译:还原因子VIII的变异以及CpG,血友病的成分和方法及治疗

摘要

It refers to the nucleic acid variant encoded by factor 8 (FVII), which has the boundary of domain B, in which the nucleic acid variant and SEC No.: 7 have the characteristics of 92% to 100%; in this factor, the nucleic acid variant contains 20% or less citosina guanidine (CPG). He also mentioned that a specific expression vector consists of a gland related viral vectorAn antiretroviral vector, an adenosine vector, a plasticizer or a slow vector, a hollow cell, and a pharmacological component, including a variant of this nucleic acid, are effective ways to treat disorders associated with abnormal hemophilia.
机译:它是指由因子8(FVII)编码的核酸变异体,其具有结构域B的边界,其中核酸变异体和SEC No .: 7具有92%至100%的特征;在该因子中,核酸变体包含20%或更少的胞嘧啶胍(CPG)。他还提到特异性表达载体由与腺相关的病毒载体组成。抗逆转录病毒载体,腺苷载体,增塑剂或慢速载体,空心细胞和药理成分(包括该核酸的变体)是有效的方法治疗与血友病异常有关的疾病。

著录项

  • 公开/公告号PE20181168A1

    专利类型

  • 公开/公告日2018-07-19

    原文格式PDF

  • 申请/专利权人 SPARK THERAPEUTICS INC.;

    申请/专利号PE20130201800

  • 发明设计人 ANGUELA XAVIER;SHEN SAM HSIEN-I;

    申请日2016-10-31

  • 分类号C07K14/755;C12N15/864;C12P21;

  • 国家 PE

  • 入库时间 2022-08-21 12:50:41

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