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Alternatives, components and methods for the reduction of CpG content of coding factor VIII and its application in the treatment of haemorrhagia
Alternatives, components and methods for the reduction of CpG content of coding factor VIII and its application in the treatment of haemorrhagia
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机译:降低编码因子VIII的CpG含量的替代物,成分和方法,及其在出血中的应用
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摘要
CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants encoding FVIII are expressed more efficiently by cells, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced expression and/or activity over wild-type Factor VIII proteins or are packaged more efficiently into viral vectors.
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