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Method for the preparation of eluent of fluorine-18 with adjusted pH, and method for labeling of fluorine-18 using the same
Method for the preparation of eluent of fluorine-18 with adjusted pH, and method for labeling of fluorine-18 using the same
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机译:调节pH值的氟18洗脱液的制备方法以及使用该方法标记氟18的方法
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摘要
The present invention relates to a method for labelling fluorine-18, which is a radioisotope, and more specifically, to a method for labelling a [ 18 F]fluoride in a method for preparing an organic [ 18 F]fluoro compound by reacting an alkyl halide or an alkyl sulfonate with a [ 18 F]fluoride, wherein a [ 18 F]fluoride supported on a quaternary alkyl ammonium polymer support is eluted using a solution containing a metal salt or a quaternary ammonium salt with an adjusted pH, and a base is not additionally used. The present invention enables a labeling reaction without an additional base after precisely reflecting the concentration of a base absolutely necessary for the nucleophilic substitution of a [ 18 F]fluoride or eluting a [ 18 F]fluoride using a [ 18 F]fluoride eluent with an adjusted pH, thereby stably obtaining a [ 18 F]fluoride-labelled compound in a high yield, and is thus useful for production of fluorine-18-labelled radioactive medical supplies.
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